Overview SARS-CoV-2

After the 1918 flu pandemic, the world is again facing a similar situation. However, the advancement in medical science has made it possible to identify that the novel infectious agent is from the coronavirus family. Rapid genome sequencing by various groups helped in identifying the structure and function of the virus, its immunogenicity in diverse populations, and potential preventive measures.

Frontiers in Immunology: Volume 11, Article 1949, 2020
Vibhuti Kumar Shah, Priyanka Firmal, Aftab Alam, Dipyaman Ganguly and Samit Chattopadhyay
Overview of Immune Response During SARS-CoV-2 Infection – Lessons From the Past

After the 1918 flu pandemic, the world is again facing a similar situation. However, the advancement in medical science has made it possible to identify that the novel infectious agent is from the coronavirus family. Rapid genome sequencing by various groups helped in identifying the structure and function of the virus, its immunogenicity in diverse populations, and potential preventive measures. Coronavirus attacks the respiratory system, causing pneumonia and lymphopenia in infected individuals. Viral components like spike and nucleocapsid proteins trigger an immune response in the host to eliminate the virus.

Proceedings of the National Academy of Sciences: vol.117, no. 17, 9241–9243, 2020
Peter Forstera, Lucy Forsterd, Colin Renfrewb, and Michael Forster
Phylogenetic network analysis of SARS-CoV-2 genomes

In a phylogenetic network analysis of 160 complete human severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) genomes, we find three central variants distinguished by amino acid changes, which we have named A, B, and C, with A being the ancestral type according to the bat outgroup coronavirus. The A and C types are found in significant proportions outside East Asia, that is, in Euro- peans and Americans. In contrast, the B type is the most common type in East Asia, and its ancestral genome appears not to have spread outside East Asia without first mutating into derived B types, pointing to founder effects or immunological or environmental resistance against this type outside Asia.

Eur J Clin Microbiol Infect Dis: 1–7, 24 apr 2020
Huihui Wang, Xuemei Li, Tao Li1, Shubing Zhang, Lianzi Wang, Xian Wu1 and Jiaqing Liu
The genetic sequence, origin, and diagnosis of SARS-CoV-2

Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV.

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